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Isopropyl alcohol

Isopropyl alcohol (IUPAC name propan-2-ol and also called isopropanol or 2-propanol) is a colorlessflammableorganic compound with a pungent alcoholic odor.

Isopropyl alcohol, an organic polar molecule, is miscible in water, ethanol, and chloroform, demonstrating its ability to dissolve a wide range of substances including ethyl cellulosepolyvinyl butyral, oils, alkaloids, and natural resins. Notably, it is not miscible with salt solutions and can be separated by adding sodium chloride in a process known as salting out. It forms an azeotrope with water, resulting in a boiling point of 80.37 °C and is characterized by its slightly bitter taste. Isopropyl alcohol becomes viscous at lower temperatures, freezing at −89.5 °C, and has significant ultraviolet-visible absorbance at 205 nm. Chemically, it can be oxidized to acetone or undergo various reactions to form compounds like isopropoxides or aluminium isopropoxide. As an isopropyl group linked to a hydroxyl group (chemical formula (CH3)2CHOH) it is the simplest example of a secondary alcohol, where the alcohol carbon atom is attached to two other carbon atoms. It is a structural isomer of propan-1-ol and ethyl methyl ether. They all have the formula C3H8O.

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Isopropyl alcohol
Skeletal formula of isopropyl alcohol
Ball-and-stick model of isopropyl alcohol
Names
Preferred IUPAC name

Propan-2-ol[2]
Other names

2-Propanol
Isopropanol[1]
Rubbing alcohol
sec-Propyl alcohol
2-Hydroxypropane
i-PrOH
Dimethyl carbinol
IPA
Identifiers
3D model (JSmol)
635639
ChEBI
ChEMBL
ChemSpider
ECHA InfoCard 100.000.601 Edit this at Wikidata
1464
KEGG
PubChem CID
RTECS number
  • NT8050000
UNII
UN number 1219

Properties
C3H8O
Molar mass 60.096 g/mol
Appearance Colorless liquid
Odor Pungent alcoholic odor
Density 0.786 g/cm3 (20 °C)
Melting point −89 °C (−128 °F; 184 K)
Boiling point 82.6 °C (180.7 °F; 355.8 K)
Miscible with water
Solubility Miscible with benzenechloroformethanoldiethyl etherglycerol; soluble in acetone
log P −0.16[3]
Acidity (pKa) 16.5[4]
−45.794·10−6 cm3/mol
1.3776
Viscosity 2.86 cP at 15 °C
1.96 cP at 25 °C[5]
1.77 cP at 30 °C[5]
1.66 D (gas)
Pharmacology
D08AX05 (WHO)
Hazards
Occupational safety and health (OHS/OSH):
Main hazards
Flammable, mildly toxic[6]
GHS labelling:
GHS07: Exclamation mark GHS02: Flammable
Danger
H225H302H319H336
P210P261P305+P351+P338
NFPA 704 (fire diamond)
NFPA 704 four-colored diamond

Health 1: Exposure would cause irritation but only minor residual injury. E.g. turpentine Flammability 3: Liquids and solids that can be ignited under almost all ambient temperature conditions. Flash point between 23 and 38 °C (73 and 100 °F). E.g. gasoline Instability 0: Normally stable, even under fire exposure conditions, and is not reactive with water. E.g. liquid nitrogen Special hazards (white): no code
Flash point Open cup: 11.7 °C (53.1 °F; 284.8 K)
Closed cup: 13 °C (55 °F)
399 °C (750 °F; 672 K)
Explosive limits 2–12.7%
980 mg/m3 (TWA), 1225 mg/m3 (STEL)
Lethal dose or concentration (LD, LC):
LD50 (median dose)
  • 12800 mg/kg (dermal, rabbit)[8]
  • 3600 mg/kg (oral, mouse)
  • 5000 mg/kg (oral, rat)[8]
  • 2364 mg/kg (oral, rabbit)
  • 16,000 ppm (rat, 4 h)
  • 12,800 ppm (mouse, 3 h)[8]
NIOSH (US health exposure limits):
PEL (Permissible)
TWA 400 ppm (980 mg/m3)[7]
REL (Recommended)
TWA 400 ppm (980 mg/m3), ST 500 ppm (1225 mg/m3)[7]
IDLH (Immediate danger)
2000 ppm[7]
Safety data sheet (SDS) [1]
Related compounds
Related alcohols
1-Propanolethanol2-butanol
Supplementary data page
Isopropyl alcohol (data page)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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